Research Trials

 Brain Imaging Research Center

Name: Jonathan Young Name: Sonet Smitherman
Phone Number: 501-526-8339 Phone Number: 501-526-8386
E-mail: JAYoung@uams.edu E-mail: SMSmitherman@uams.edu

 

Study Title Description (Purpose, population, eligibility criteria, etc.)
Neuroimaging Individual Differences in Cognition: A Pilot StudyStudy Coordinator:  Jonathan We are exploring the differences in how people think and the variability on brain networks by using fMRI to identify areas of the brain that are activated during different tasks. We are comparing healthy adults to those that use cocaine and those that have epilepsy. We are recruiting healthy control subjects (M/F ages 18-50) without drug use disorders, psychiatric disorders, or serious medical conditions. No internal or non-removable metal or medical implants. Participating involves completion of a confidential interview, questionnaires, and two MRI scans. Requires 3-4 visits. Total time = ~9 hours. Compensation will be provided.
Neural Network Predictors of Treatment Outcome Among Adolescent Assault VictimsStudy Coordinator:  Sonet The purpose of this study is to understand the relationship between brain function and effectiveness of a treatment method for adolescent PTSD. We are recruiting adolescent females, ages 11-16 with current PTSD due to physical or sexual assault. No serious medical conditions. No internal or non-removable metal or medical implants. Adolescents will participate in an intake visit consisting of confidential interviews and questionnaires and an MRI scan, followed by 12 weeks of trauma focused cognitive behavioral therapy. Assessments and an MRI scan will also be completed post treatment and assessments (no scan) at 3 months following treatment. Parents complete a series of questionnaires before and after treatment and at the 3 month follow up. Total time for adolescent at each assessment = ~3 hrs. 12 therapy sessions last ~60-90 minutes. Total time for parent at each assessment = ~1 hr. Compensation will be provided.
An fMRI Study of the Impact of Stress on Drug Addiction, part 2Study Coordinator:  Jonathan The purpose of this study is to learn about how decision making and impulsivity are related to cocaine addiction. We are going to compare healthy adults to those that use cocaine and those with a traumatic early life history. We are currently only recruiting female cocaine users, ages 18-50, with or without an early life history of abuse or neglect. No serious medical conditions. No internal or non-removable metal or medical implants. Participating involves completing a series of interviews and questionnaires and two MRI brain scans during 2-4 visits. Total time = ~7 hours. Compensation will be provided.
Neural Mechanisms of Associative Learning among Individuals with PTSDStudy Coordinator:  Sonet The purpose of this study is to understand the neural mechanisms mediating social and non-social associative learning among females with PTSD. The study will compare healthy females without a diagnosis of PTSD to those that do have PTSD to see how they might differ in relation to social learning. We are currently recruiting females, ages 18-55, with and without PTSD. No serious medical conditions. No internal or non-removable metal or medical implants. Participating involves completing a series of interviews and questionnaires and one MRI brain scan during 1-2 visits. Total time = ~5 hours. Compensation will be provided.

Women’s Mental Health Program

E-mail: BTKnight@uams.edu

 

Name: Bettina Knight
Phone Number: 501-526-8432
Study Title Description (Purpose, population, eligibility criteria, etc.)
Stress in PregnancyStudy Coordinator: Bettina The purpose of this study is to learn more about babies born to women and teenage girls under stress. The study will also help us determine why some of the babies develop normally and others have problems with their emotional and social development. Women enrolled in the study will be between 18-45 years of age. There is a separate consent for teenage girls between the ages of 13-17 years of age. By participating in this study the subject is not required to use medications although medication and therapy are not an exclusion. The study simply monitors the progress of any treatment that the subject may already be receiving or may choose to receive after enrolling in this study. Most study visits will take place at the Women’s Mental Health Program on the 4th floor in the Psychiatric Research Institute building on the UAMS campus. Depending on how early in pregnancy the subject enrolls in the study, they will have an enrollment visit and a minimum of 3 follow-up visits during pregnancy. These will take place during the 1st, 2nd and 3rd trimesters. A minimum of 4 follow-up visits will take place after the baby is born at around postpartum weeks 6, 18, 24, and 52. Compensation will be provided.