Research Trials

Brain Imaging Research Center

Study Title Description
A Risk Factor Analysis of Human Brain States Related to the Development of Addiction The goal of this study is to understand how stress and drug use or non-use is related and to understand how this affects the brain. We are looking for teenage girls and adult women to participate in this study.For adolescents, participation involves 2 separate visits. The participant and a parent will be asked to come to the Brain Imaging Research Center at UAMS. Both adolescent and their parent will complete a series of interviews and questionnaires. Some of the questions we ask will be about how the adolescent has been feeling, if they have ever been in a stressful or abusive situation, and about any drug use. This visit takes about 4 hours to complete. Following this first visit the adolescent will come back one more time to complete the MRI scan. The MRI scan takes about 1 ½ hours to complete. Finally, we will contact the adolescent 3 separate times by phone over a 9 month period to ask about any drug use since the last visit. All information that we collect throughout the study is kept confidential. Also, we do not tell parents about any drug use the adolescent reports to us. Both adolescent and parent participants will be compensated for their time.

Eligibility Criteria

 

Female

Ages 12-16

Medically healthy

No internal metals

Must have a parent able to stay for each visit

Please contact Sonet Smitherman at 501-526-8386 or SMSmitherman@uams.edu for more information

 

For adults, participation involves 2 separate visits. The participant will be asked to come to the Brain Imaging Research Center at UAMS. They will complete a series of interviews and questionnaires. Some of the questions we ask will be about how the adolescent has been feeling, if they have ever been in a stressful or abusive situation, and about any drug use. This visit takes about 4 hours to complete. Following this first visit the adolescent will come back one more time to complete the MRI scan. The MRI scan takes about 1 ½ hours to complete.

Eligibility Criteria

 

Female

Ages 25-40

Medically healthy

No internal metals

Must have started using drugs between age 12-16 years

Must have abused at least 2 drugs at some point during your life

Please contact Jonathan Young at 526-8339 or JAYoung@uams.edu for more information.

Study Title Description
A Pilot Study on the Trajectory of Cocaine Addiction The purpose of this research is to study the path of drug use across a period of two months in adult cocaine users. Study participation involves three visits to the Brain Imaging Research Center at UAMS. At the first visit participants will be asked to complete questionnaires and interviews about their background, psychological functioning, recent life experiences, and drug use history. The first visit takes about 3 hours to complete. One month and two months following the first visit, participants will be asked to come back in to complete a few more questionnaires. These visits will take about 1-2 hours each. Participants will be compensated for their time.Eligibility Criteria

Male or Female

Ages 18-50

Good general health

Crack or cocaine use within the past 30 days

Please contact Jonathan Young at 501-526-8339 or jayoung@uams.edu for more information.

Study Title Description
Psychiatric Illness and Postpartum Maternal Sensitivity and Motivation for Offspring The quality of maternal care received early in life is a major determinant of a child’s wellbeing and success in life. Some psychiatric issues, such as depression or drug use, are thought to interfere with a mother’s ability to provide care for her child. Researchers at the Brain Imaging Research Center and in the Women’s Mental Health Program are conducting a pilot study to develop computer tasks that will determine how psychiatric illness influences maternal behavior in the early postpartum period.

We are currently recruiting mothers who have given birth within the last eight weeks and fall into one of the three following categories:

  • have major depression,
  • have opiate dependence, or
  • don’t have major depression or drug use disorders

Study participants will be asked to submit a urine sample and complete interviews and questionnaires related to their mental health, drug use, recent life events and feelings about motherhood. They will also be asked to complete computer tasks of attention and decision making and to give a brief interview afterwards to inform us on how the tasks can be improved. Completion of all study procedures requires only one visit to the Psychiatric Research Institute that is expected to last 3-4 hours. Participants will be compensated for their time and bus fare or parking costs.

Please contact Dr. Lisa Brents at (501) 413-6058 or LBRENTS@uams.edu for more information.

Study Title Description
Psychiatric Illness and Postpartum Neural Representations of Maternal Care The purpose of this study is to help us understand how psychiatric conditions like depression and drug use disorders affect maternal behaviors and brain function. Participants would be asked to complete interviews and questionnaires related to medical and psychological history, recent life events, drug use, and motherhood. Participants will also be asked to complete an MRI scan. Completion of study procedures may require 1-2 visits to UAMS and take ~5 hours total to complete. Participants will be compensated for their time and bus fare of parking costs.

We are currently recruiting mothers who have given birth within the last eight weeks, with no internal metal objects, and fall into one of the three following categories:

  • have major depression,
  • have opiate dependence, or
  • don’t have major depression or drug use disorders

Please contact Dr. Lisa Brents at 501-413-6058 or LBRENTS@uams.edu for more information.

Study Title Description
Family Decision-Making and Adolescent PTSD The purpose of the present study is to compare patterns of family cooperative behavior between assaulted and non-assaulted adolescent girls and identify the impact of family cooperative behavior on brain representations of trust among the adolescents. Participation in the study will occur over a 6-month period, with 4 visits to UAMS. Participants will be asked to complete interviews and questionnaires related to their trauma history, current and past psychological history, and family behaviors, play a decision-making game with other members of their family, and complete an MRI scan. Total time for participating is ~10 hours over a 6-month period. Compensation will be provided for both the child and their parents/caregivers.

Eligibility Criteria

Female

11-17 years of age

No internal metal

No major medical condition

History of physical or sexual assault

2 caregivers available to participate

Please contact Sonet Smitherman at 501-526-8386 or SMSmitherman@uams.edu for more information.

Study Title Description
Real-time fMRI and Neurofeedback of Brain Networks Mediating Trauma Memory Recall in PTSD The purpose of this study is to identify how the brain performs while recalling stressful or traumatic experiences. Participants in this study would be asked to complete interviews and questionnaires and an MRI scan. Participation would involve completion of interviews and questionnaires related to possible history of trauma, mental health history, and physical health history, and completion of an MRI scan. Participation would require two 3-hour visits to UAMS, taking ~6 hours to complete. Compensation will be provided.

Eligibility Criteria

Female

21-50 years of age

With our without a history of physical or sexual assault

No internal metal

No major medical condition

Please contact Sonet Smitherman at 501-526-8386 or SMSmitherman@uams.edu for more information.

Women’s Mental Health Program

Study Title Description
Table Table
Name: Bettina Knight
Phone Number: 501-526-8432
Study Title Description (Purpose, population, eligibility criteria, etc.)
Stress in PregnancyStudy Coordinator: Bettina The purpose of this study is to learn more about babies born to women and teenage girls under stress. The study will also help us determine why some of the babies develop normally and others have problems with their emotional and social development. Women enrolled in the study will be between 18-45 years of age. There is a separate consent for teenage girls between the ages of 13-17 years of age. By participating in this study the subject is not required to use medications although medication and therapy are not an exclusion. The study simply monitors the progress of any treatment that the subject may already be receiving or may choose to receive after enrolling in this study. Most study visits will take place at the Women’s Mental Health Program on the 4th floor in the Psychiatric Research Institute building on the UAMS campus. Depending on how early in pregnancy the subject enrolls in the study, they will have an enrollment visit and a minimum of 3 follow-up visits during pregnancy. These will take place during the 1st, 2nd and 3rd trimesters. A minimum of 4 follow-up visits will take place after the baby is born at around postpartum weeks 6, 18, 24, and 52. Compensation will be provided.