Jeffrey M. Pyne, M.D.


Professor, Department of Psychiatry and Behavioral Sciences, College of Medicine, University of Arkansas for Medical Sciences
Associate Professor, Division of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences
Associate Professor, Department of Epidemiology, College of Public Health, University of Arkansas for Medical Sciences
Staff Physician, Central Arkansas Veterans Healthcare System
Associate Director for Research and Site Leader, South Central (VISN 16) Mental Illness Research, Education, and Clinical Center (MIRECC)
Research Health Scientist and Core Investigator, Center for Mental Healthcare and Outcomes Research (CeMHOR)


UAMS Phone: 501-526-8115
VA Phone: 501-257-1083
UAMS E-mail:
VA E-mail:
Administrative assistant Mitzi Mosier: or 501-257-1084

Research Expertise

Dr. Pyne is trained as an adult psychiatrist and completed a NIMH Psychopharmacology Fellowship. Dr. Pyne has conducted cost-effectiveness analyses across a variety of mental health conditions and treatments; developed and tested collaborative care telemedicine interventions, psychophysiologic reactivity assessments, medication adherence interventions, and clergy/clinician collaboration.

Current Research Interests: cost-effectiveness analysis, telemedicine-based collaborative care, psychophysiologic assessment, and clergy/clinician collaboration.

Recent Publications

Current publications, 2009-2016

  1. Fortney JC, Unutzer J, Wrenn GL, Pyne JM, Smith GR, Schoenbaum ML, Harbin HT.  A tipping point for measurement based care. In Review
  2. Pyne JM, Constans JI, Wiederhold MD, Gibson DP, Kimbrell T, Kramer TL, Pitcock JA, Han X, Chartrand D, Gevirtz RN, Spira J, Wiederhold BK, McCraty R, McCune TR. Heart rate variability: an objective pre-deployment predictor of post-deployment PTSD. In Review.
  3. Zuchowski JL, Hamilton AB, Pyne JM, Clark JA, Naik AD, Smith DL, Kanwal F. Qualitative analysis of patient-centered decision attributes associated with initiating hepatitis C treatment. Journal: BMC Gastroenterology.  In Press.
  4. Grubbs KM, Fortney JC, Kimbrell T, Pyne JM, Hudson T, Robinson D, Moore WM, Custer P, Schneider R, Schnurr P. Predictors of cognitive processing therapy (CPT) utilization among Veterans in collaborative care. Journal of Traumatic Stress. In Press.
  5. Fortney JC, Pyne JM, Turner E, Farris K, Normoyle T, Avery M, Hilty D, Unützer J. (2015)  Telepsychiatry Integration of Mental Health Services into Rural Primary Care Settings, International Review of Psychiatry. 27(6):525-539.
  6. Tilford JM, Payakachat N, Kovacs E,  Pyne JM, Brouwer W, Nick T, Bellando J, Kuhlthau K.  Treatment for sleep problems in children with autism and caregiver spillover effects.  Journal of Autism and Developmental Disorders.  2015 Jul 1. [Epub ahead of print] PubMed PMID: 26126749.
  7. Painter JT, Fortney JC, Gifford AL, Rimland D, Monson T, Rodriguez-Barradas MC, Pyne JM. (2015)  Cost-effectiveness of collaborative care for depression in Human Immunodeficiency Virus clinics. Journal of Acquired Immune Deficiency Syndromes. Dec 1;70(4):377-85.  [Epub ahead of print] PubMed PMID: 26126749.
  8. Pyne JM.  Expanding the Scope of Integrated Behavioral Health Care for Patients with HCV.  Clinical Gastroenterology and Hepatology.  2015 May 5.[Epub ahead of print] PubMed PMID: 25952310.
  9. Fischer EP, Sherman MD, McSweeney JC, Pyne JM, Owen RR, Dixon LB.  Perspectives of family and Veterans on family programs to support reintegration of returning Veterans with PTSD.  Psychological Services. 12(3):187-198.
  10. Call DW, Pitcock J, Pyne JM. Longitudinal evaluation of the relationship between mindfulness, general distress, anxiety, and PTSD in a recently deployed National Guard sample. Mindfulness.  April 6. doi: 10.1007/s12671-015-0400-0 [Epub ahead of print]
  11. Zuchowski JL, Hamilton AB, Pyne JM, Clark JA, Naik AD, Smith DL, Kanwal F.  Patient-centered factors associated with hepatitis C treatment: a qualitative study.  BMC Gastroenterology  In Press.
  12. Hudson T, Fortney JC, Mittal D, Pyne JM.  (2015) Reduction of patient-reported antidepressant side effects in collaborative care.  Psychiatric Services.  Mar 1;66(3):272-8. Epub 2014 Dec 1.  PMID:25727115
  13. Brady RE, Constans JI, Marx BP, Spira JL, Gevirtz R, Kimbrell TA, Kramer TL, Pyne JM.  Effect of symptom over-reporting on heart rate variability in Veterans with PTSD.  Journal of Trauma & Dissociation. 2015 May 26:1-12. [Epub ahead of print] PubMed PMID: 26011249.
  14. Nanney JT, Constans JI, Kimbrell TA, Kramer TL, Pyne JM.  Differentiating between appraisal process and product in cognitive theories of posttraumatic stress.  Psychological Trauma: Theory, Research, Practice, and Policy.  2015 Jul;7(4):372-81. Epub 2014 Dec 22. PubMed PMID: 26147520; PubMed Central PMCID: PMC4494123.
  15. Kuhlthau K, Payakachat N, Delahaye J, Hurson J, Pyne JM, Kovacs E, Tilford JM. Quality of life for parents of children with autism spectrum disorders.  Research in Autism Spectrum Disorders.   In Press.
  16. Pyne JM, Fortney JC, Mouden SB, Lu L, Hudson TJ, Mittal D.  Cost Effectiveness of On-site versus Off-site Depression Collaborative Care in Rural Federally Qualified Health Centers.  Psychiatric Services. 2015 May 1;66(5):491-9. Epub 2015 Feb 17. PubMed PMID: 25686811.
  17. Fortney JC, Pyne JM, Kimbrell TA, Hudson TJ, Robinson DE, Schneider R, Moore WM, Custer PJ, Grubss KM, Schnurr PP. (2015) Pragmatic randomized trial of telemedicine-based collaborative care for posttraumatic stress disorder. JAMA Psychiatry. Jan 1;72(1):58-67. PubMed PMID: 25409287.
  18. Fortney JC, Pyne JM, Burgess JF.  (2014) Population level cost effectiveness of implementing evidence based practices into routine care.  Health Services Research.  Dec;49(6):1832-51.  Epub 2014 Oct 18.  PMID:25328029 (published in the “Best of the 2014 Academy Health Annual Research Meeting” special section)
  19. Hoefman R, Payakachat N, van Exel J, Kuhlthau K, Kovacs E, Pyne J, Tilford JM. (2014)  Careing for a child with autism spectrum disorder and parents’ quality of life: application of the CarerQol. Journal of Autism Developmental Disorders.  Aug;44(8):1933-45. PMID:24577786
  20. Payakachat N, Tilford JM, Kuhlthau K, van Exel J, Kovacs E Bellando J, Pyne JM, Brouwer WBF. (2014) Predicting health utilities for children with autism spectrum disorders. Autism Research.  Dec;7(6):649-63. Epub 2014 Sep 25. PMID:25255789
  21. Wood DP, Mclay RL, Webb-Murphy J, Wiederhold MD, Spira JL, Pyne JM, Wiederhold BK. (2014) Virtual reality graded exposure therapy with arousal control for the treatment of combat related posttraumatic stress disorder: a follow up case series. Stud Health Technol Inform. 199:141-5. PubMed PMID: 24875708.
  22. Pyne JM, Fischer EP, Gilmore L, McSweeney J, Stewart KE, Mittal D, Bost JE, Valenstein M. (2014) Development of a patient-centered antipsychotic medication adherence intervention. Health Education & Behavior. Jun 41(3):315-324 (Epub ahead of print Dec 25, 2013) PubMed PMID: 24369177
  23. Sullivan G, Hunt J, Haynes TF, Bryant K, Cheney AM, Pyne JM, Reaves C,
  24. Sullivan S, Lewis C, Barnes B, Barnes M, Hudson C, Jegley S, Larkin B, Russell S,
  25. White P, Gilmore L, Claypoole S, Smith J, Richison R. (2014).  Partnering with rural faith communities to promote mental health: A multi-site program for veterans.  Progress in Community Health Partnerships: Research, Education, and Action.  Spring;8(1):11-9.
  26. PubMed PMID: 24859098.
  27. Constans JI, Kimbrell TA, Nanney JT, Marx BP, Jegley S, Pyne JM. (2014) Over-reporting bias and the modified Stroop effect in OEF/OIF Veterans with and without PTSD. Journal of Abnormal Psychology. Feb; 123(1):81-90.  Nov 25 (Epub ahead of print) PubMed PMID: 24274375
  28. Sullivan S, Pyne JM, Cheney AM, Hunt J, Haynes TF, Sullivan G. (2014) The pew versus the couch: Relationship between mental health and faith communities and lessons learned from a VA/Clergy partnership project. Journal of Religion and Health. Aug; 53(4): 1267-82. PubMed PMID: 23775218
  29. Fortney JC, Enderle MA, Clothier, JL, Otero JM, Williams JS, Pyne JM. (2013) Population level effectiveness of implementing collaborative care management for depression.  General Hospital Psychiatry. Sep-Oct; 35(5): 455-60. Epub 2013 May 30.  PubMed PMID: 23725825
  30. Davis-Lee EA, Carter MA,Bissett JK, Cowan PA, Pyne JM, Speck PM, Theus SA, Tolley EA.  Preliminary findings of the relationship of lower heart rate variability with military sexual trauma and presumed posttraumatic stress disorder.  Journal of Traumatic Stress. 2013 Apr; 26(2):249-56. PubMed PMID: 23568414
  31. Fortney JC, Pyne JM, Mouden SB, Mittal D, Hudson TJ, Schroeder GW, Williams DK, Bynum CA, Mattox R, Rost KM.  (2013) Practice based versus telemedicine based collaborative care for depression in rural Federally Qualified Health Centers: A pragmatic randomized comparative effectiveness trial.  American Journal of Psychiatry. April 1; 170(4) 4: 414-25. PubMed PMID: 23429924.
  32. Fortney JC, Pyne JM, Simon GE, Ludman EJ. Response to White. American Journal of Psychiatry. 2013 Aug 1;170(8):926-7. PubMed PMID: 23903337
  33. Kramer TL, Savary PE, Pyne JM, Kimbrell TA, Jegley SM. (2013) Veterans’ perceptions of virtual reality to assess and treat Post-Traumatic Stress Disorder.  Cyberpsychology, Behavior and Social Networking.  Apr;16(4):293-301. PubMed PMID: 23574368
  34. Tilford JM, Payakachat N, Kovacs E,  Pyne JM, Brouwer W, Nick T, Bellando J, Kuhlthau K.  (2012) Preference-based health-related quality of life outcomes in children with autism spectrum disorders: A comparison of generic instruments.  Pharmacoeconomics.  Aug 1;30(8):661-79. PubMed PMID:  22788258
  35. Bottonari KA, Tripathi SP, Fortney JC, Curran G, Rimland D, Rodriguez-Barradas M, Gifford AL,  Pyne JM. (2012) Correlates of antiretroviral and antidepressant adherence
    among depressed HIV-infected patients.  AIDS Patient Care and STDS.  May 26(5):265-73.  PubMed PMID: 22536930
  36. Curran GM, Bauer M, Mittman B, Pyne JM, Stetler C. (2012) Effectiveness-implementation hybrid designs: Combining elements of clinical effectiveness and implementation research to enhance public health impact. Medical Care.  Mar 50(3):217-26.  PubMed PMID: 22310560
  37. McLay RN, Grapp K, Spira JL, Perlman K, Johnston SL, Rothbaum BO, Difede J, Deal W, Schilling R, Oliver D, Baird A, Bordnick PS, Spitalnick J, Pyne JM, Rizzo A. (2012)  Development and testing of virtual reality exposure therapy for post traumatic stress disorder in active duty service members who served in Iraq and Afghanistan.  Military Medicine. Jun 177(6):635-42.  PubMed PMID: 22730837
  38. Kimbrell T,  Pyne JM, Kunik ME, Magruder KM, Petersen NJ, Yu HJ, Hudson TJ, Schulz PE, Qureshi SU. (2011) The impact of Purple Heart commendation and PTSD on mortality rates in older veterans.  Depression and Anxiety.  Dec 21;28(12):1086-90. (July 12 Epub ahead of print) PubMed PMID: 21751302
  39. Curran GM, Pyne J, Fortney JC, Gifford A, Asch SM, Rimland D, Rodriguez-Barradas M, Munson TP, Kilbourne AM, Hagedorn H, Atkinson JH. (2011) Development and implementation of collaborative care for depression in HIV clinics.  AIDS Care. Dec 23(12):1626-36. Epub 2011 June 30. PubMed PMID: 21714689
  40. Deen TL, Fortney JC, Pyne JM.  (2011) Relationship between satisfaction, patient-centered care, adherence, and outcomes among patients in a collaborative care trial for depression. Administration and Policy in Mental Health and Mental Health Services Research.  Sep; 38(5): 345-55. PubMed PMID: 20978932
  41. Fortney JC, Pyne JM, Edlund MJ, Stecker T, Mittal D, Robinson DE, Henderson KL. (2011) Reasons for antidepressant non-adherence among veterans treated in primary care clinics. Journal of Clinical Psychiatry. Jun; 72(6): 827-34. Epub 2010 Nov 16. PubMed PMID: 21208579
  42. Fortney JC, Maciejewski ML, Tripathi, SP, Deen TL, Pyne JM. (2011)  A budget impact analysis of telemedicine-based collaborative care for depression.  Medical Care.  Sep;49(9):872-880.  PubMed PMID: 21623240
  43. Wood DP, Webb-Murphy J, McLay RN, Wiederhold BK, Spira JL, Johnston S, Koffman
    RL, Wiederhold MD, Pyne J. (2011) Reality graded exposure therapy with physiological monitoring for the treatment of combat related post traumatic stress disorder: a
    pilot study. Studies in Health Technology and Informatics. 163:696-702. PubMed PMID: 21335883
  44. McLay RN, Wood DP, Webb-Murphy JA, Spira JL, Wiederhold MD, Pyne JM,
    Wiederhold BK. (2011) A randomized, controlled trial of virtual reality-graded exposure
    therapy for post-traumatic stress disorder in active duty service members with
    combat-related post-traumatic stress disorder. Cyberpsychology, Behavior and Social Networking.  Apr;14(4):223-229.  PubMed PMID: 21332375                                                                            
  45. Pyne JM, Tripathi S, French M, McCollister K, Rapp RC, Booth BM. (2011)  Longitudinal association of preference-weighted health-related quality of life measures and substance use disorder outcomes.  Addiction. 106(3):507-15. PubMed PMID: 21205046
  46. Qureshi S, Long ME, Bradshaw MR, Pyne JM, Magruder KM, Kimbrell T, Hudson TJ, Jawaid A, Schulz PE, Kunik ME. (2011)  Does PTSD impair cognition beyond the effect of trauma?  The Journal of Neuropsychiatry and Clinical Neurosciences. 23(1):16-28. PubMed PMID: 21304135
  47. Pyne JM, Fortney JC, Curran GM, Tripathi S, Atkinson JH, Kilbourne AM, Hagedorn HJ, Rimland D, Rodriguez-Barradas MC, Monson T, Bottonari KA, Asch SM, Gifford AL.  (2011)  Effectiveness of collaborative care for depression in human immunodeficiency virus clinics.  Archives of Internal Medicine. 171(1):23-31. PubMed PMID: 21220657
  48. Mittal D, Fortney JC, Pyne JM, Wetherell JL.  (2011) Predictors of persistence of co-morbid generalized anxiety disorder among veterans with major depression.  Journal of Clinical Psychiatry. Nov; 72(11):1445-51.  Epub 2010 Dec 14. PubMed PMID: 21208594
  49. Fortney JC, Pyne JM, Edlund MJ, Mittal D.  (2010) Relationship between antidepressant medication possession and treatment response. General Hospital Psychiatry. Jul-Aug; 32(4): 377-9. Epub 2012 May 4. PubMed PMID: 20633741
  50. Pyne JM.  Commentary on Dietze et al: Moving patient-centered health outcomes forward. (2010)  Addiction. 105(12):2149-50. PubMed PMID: 21108510
  51. Fortney, JC, Pyne JM, Steven CA, Williams JS, Hedrick RG, Lunsford AK, Raney WN, Ackerman BA, Bonner, LM, Smith JL. (2010) A web-based clinical decision support system for depression care management.  American Journal of Managed Care. 16(11):849-854. PubMed PMID: 21348556
  52. Kramer T, Pyne J, Kimbrell T, Savary P, Smith J, Jegley S. (2010) Clinician perceptions of virtual reality to assess and treat returning veterans.  Psychiatric Services. 61(11):1153-1156.  PubMed PMID: 21041358
  53. Qureshi SU, Kimbrell T, Pyne JM, Magruder KM, Hudson TJ, Petersen NJ, Yu HJ, Schulz PE, Kunik ME. (2010) Greater prevalence and incidence of dementia in older veterans with PTSD.  Journal of the American Geriatrics Society.   58:1627-1633. PubMed PMID: 20863321
  54. Pyne JM, Fortney JC, Tripathi S, Maciejewski ML, Edlund MJ, Williams DK.  (2010) Cost effectiveness analysis of a rural telemedicine collaborative care intervention for depression.  Archives of General Psychiatry. 67:812-821.  Abstract was re-printed in Journal of the American Medical Association.  (2010) 304(13):1425. PMID: 20679589
  55. Wood DP, Murphy J, Center K, McLay R, Koffman R, Johnston S, Spira J, Pyne JM, Wiederhold B. (2009) Combat related post traumatic stress disorder: A case report using virtual reality graded exposure therapy with physiological monitoring with a female seabee. Military Medicine. 174(11):1215-22. PMID: 19960832
  56. Wood DP, Murphy J, McLay R, Koffman R, Spira J, Obrecht RE, Pyne J, Wiederhold BK.  (2009) Cost effectiveness of virtual reality graded exposure therapy with physiological monitoring for the treatment of combat related post traumatic stress disorder.  Studies in Health Technology and Informatics. 144:223-9. PMID: 19592768
  57. McCollister KE, French MT, Pyne JM, Booth B, Rapp R, Carr C. (2009) The cost of treating addiction from the client’s perspective: Results from a multi-modality application of the Client DATCAP.  Drug and Alcohol Dependence.  104(3): 241-248. PMID: 19574000
  58. Qureshi S, Pyne JM, Magruder K, Schulz PE, Kunik ME. (2009) The link between post-traumatic stress disorder and physical comorbidities: A systematic review.  Psychiatric Quarterly.   80(2): 87-97. PMID: 19291401
  59. Pyne JM, Fortney J, Tripathi S, Feeny D, Ubel P, Brazier J.  (2009) How bad is depression? Preference score estimates from depressed patients and the general population.  Health Services Research. 44(4): 1406-23. PMID: 19453391
  60. Fortney J, Pyne JM, Smith J, Curran G, Otero J, Enderle M, McDougall S.  (2009) Steps for Implementing Collaborative Care Programs for Depression.  Population Health Management. 12(2): 69-79. PubMed PMID: 19320606
  61. Ackerman B, Pyne JM, Fortney J. (2009) Challenges associated with being an off-site depression care manager.  Journal of Psychosocial Nursing and Mental Health, 47(4) 43-49. PubMed PMID: 19437931
  62. Liu CF, Rubenstein LV, Kirchner JE, Fortney JC, Perkins MW, Ober SK, Pyne JM, Chaney EF.  (2009) The organizational cost of quality improvement for depression care.  Health Services Research, 44(1):225-44. PubMed PMID: 19146566